D-A-HYDROXYGLUTARIC ACID DISODIUM
D-α-Hydroxyglutaric acid disodium salt
CAS: 103404-90-6
Molecular Formula: C5H6Na2O5
D-A-HYDROXYGLUTARIC ACID DISODIUM - Names and Identifiers
D-A-HYDROXYGLUTARIC ACID DISODIUM - Physico-chemical Properties
| Molecular Formula | C5H6Na2O5 |
| Molar Mass | 192.08 |
| Melting Point | >291°C (dec.) |
| Appearance | White powder |
| BRN | 5318041 |
| Storage Condition | -20°C |
| MDL | MFCD00069573 |
| Use | An α hydroxy acid |
| In vitro study | In U-87MG cells,(R)-2-Hydroxyglutarate as a weak antagonist of α-kg inhibited α-kg-dependent histone demethylase and increased the dimethylation of H3K9 and H3K79. In addition,(R)-2-Hydroxyglutarate Inhibits ATP synthase and mTOR signaling, thereby causing growth arrest and tumor cell killing. |
| In vivo study | D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO 2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism. D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors. D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats. |
D-A-HYDROXYGLUTARIC ACID DISODIUM - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29181990 |
D-A-HYDROXYGLUTARIC ACID DISODIUM - Reference Information
| Biological activity | Disodium (R)-2-Hydroxyglutarate (D-α-Hydroglutaric acid disodium) is a competitive alpha-ketoglutarate-dependent dioxygenases inhibitor with a Ki value of 10.87±1.85 mM. |
| Target | Value |
Last Update：2024-04-09 15:16:50
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Product Name: D-α-Hydroxyglutaric acid disodium salt Visit Supplier Webpage Request for quotationCAS: 103404-90-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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